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We discuss the implications of HDAC6 as a critical regulator for the status of tau acetylation, pathogenesis, and cognitive function. While histone deacetylases (HDACs) are implicated in aging and neurodegeneration, we show that HDAC6 in particular mediates tau deacetylation. However, it remains unclear which enzymes regulate neuronal tau acetylation. Interestingly, acetylation abundantly decorates the microtubule binding region, thereby inducing the pathophysiological conversion of microtubule binding tau to aggregated tau.
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In particular, acetylated tau has been recently implicated in neurodegeneration and cognitive decline. “Tauopathies are a group of progressive neurodegenerative diseases marked by the accumulation of aberrantly modified tau proteins. Hanna Trzeciakiewicz, Biochemistry and Biophysics 2020 Dean’s Distinguished Dissertation Award, Biological and Life Sciences The Regulation of Tau Pathogenesis in Neurodegeneration On behalf of our University community, I thank our graduate students for all that they do.” They seek collaboration, value compassion and apply their knowledge in novel ways. Graduate students establish important connections between UNC-Chapel Hill and communities across North Carolina and around the world. They teach undergraduate students with enthusiasm and encouragement, they support efforts that recognize our University’s faculty and staff members, and they participate in service that benefits our local community.
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Even as they work toward carefully considered academic and professional goals, Carolina’s graduate students are also motivated to help others on our campus succeed. I’m truly inspired by Carolina’s graduate students. Their hard work and dedication in solving the world’s challenges and training the next generation of leaders is critical to our commitment to being the leading global public research university.
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Working closely with faculty mentors, graduate students at Carolina pursue innovative discoveries and lead efforts that make a difference in North Carolina and beyond. “Graduate students are essential to our University’s research, teaching and service.